Pinson R A, Dretchen K L, Kruger G O
Arch Int Pharmacodyn Ther. 1976 Jan;219(1):52-63.
2-(4'-pyridyl)-1,3-dioxolane methiodide (KCL-301-14) and 2-(1'-methyl-4' piperidyl)-1,3-dioxolane hydroiodide (KCL-301-39) facilitated the force of contraction in low doses and blocked it in higher doses in the in vivo cat soleus muscle preparation. Both drugs in the cat also reversed d-tubocurarine and succinylcholine blockade, produced post-drug repetitive activity, blocked post-tetanic potentiation (PTP), had no direct muscle affect and reversed the PTP suppression caused by d-tubocurarine and succinylcholine. In the rat phrenic nerve-diaphragm and the chick biventer cervicis preparations in vitro, facilitation, then blockade of the contraction were seen as concentrations increased. However, KCL-301-14 reversed d-tubocurarine and increased succinylcholine blockades in the rat and chick. KCl-301-39 increased both d-tubocurarine and succinylcholine blockades in the rat and chick. The different effects seen in the cat vs. the rat and chick with these drugs are probably due to species variation.
2-(4'-吡啶基)-1,3-二氧戊环甲碘化物（KCL-301-14）和2-(1'-甲基-4'-哌啶基)-1,3-二氧戊环氢碘化物（KCL-301-39）在低剂量时促进体内猫比目鱼肌的收缩力，而在高剂量时则阻断收缩力。在猫体内，这两种药物还能逆转筒箭毒碱和琥珀酰胆碱的阻断作用，产生药物后重复活动，阻断强直后增强（PTP），对肌肉无直接影响，并能逆转由筒箭毒碱和琥珀酰胆碱引起的PTP抑制。在体外大鼠膈神经-膈肌和鸡双颈肌制备中，随着浓度增加，先出现收缩力增强，随后出现收缩力阻断。然而，KCL-301-14能逆转大鼠和鸡体内筒箭毒碱的作用，并增强琥珀酰胆碱的阻断作用。KCl-301-39能增强大鼠和鸡体内筒箭毒碱和琥珀酰胆碱的阻断作用。这些药物在猫与大鼠和鸡身上产生的不同效应可能是由于物种差异。
