Wei Zhifeng, Ye Zhangqun, Chen Zhiqiang
Department of Urology, Nanjing General Hospital of Nanjing Military Command of PLA, Nanjing 210002, Jiangsu, China.
J Huazhong Univ Sci Technolog Med Sci. 2007 Aug;27(4):437-9. doi: 10.1007/s11596-007-0422-5.
To examine the expression of human telomere reverse transcriptase (hTERT), p53 and proliferating cell nuclear antigen (PCNA) in cystitis glandularis, 38 patients were divided into two groups: group A (including 18 cases of papillary cystitis glandularis) and group B (including 20 subjects with normal bladder mucosa). All the cases were immunohistochemically examined by using antibodies specifically against p53 and PCNA, and hTERT was determined by in situ hybridization. hTERT was found in 6 cases (33.3%) and p53 was detected in 4 cases (22.2%) in group A, while they were not detected in group B. There were significant differences in hTERT and p53 expression between groups A and B (P<0.05 for both). PCNA was detected in 7 cases (38.9%) in group A and 1 case (5.0%) in group B, and significant difference in PCNA expression was found between the two groups (P<0.05). The expressions of hTERT, p53 and PCNA were significantly higher in group A than in group B, suggesting that papillary cystitis glandularis is predisposed to cancerous change, and p53, PCNA, hTERT may be related to the malignant alteration.
为检测腺性膀胱炎中人类端粒逆转录酶（hTERT）、p53和增殖细胞核抗原（PCNA）的表达，将38例患者分为两组：A组（包括18例乳头状腺性膀胱炎）和B组（包括20例膀胱黏膜正常者）。所有病例均采用抗p53和PCNA的特异性抗体进行免疫组织化学检测，hTERT通过原位杂交测定。A组6例（33.3%）检测到hTERT，4例（22.2%）检测到p53，而B组未检测到。A组和B组之间hTERT和p53表达存在显著差异（两者P均<0.05）。A组7例（38.9%）检测到PCNA，B组1例（5.0%）检测到PCNA，两组之间PCNA表达存在显著差异（P<0.05）。A组中hTERT、p53和PCNA的表达明显高于B组，提示乳头状腺性膀胱炎易发生癌变，且p53、PCNA、hTERT可能与恶性改变有关。
