Friedman N Deborah, Bull Ann L, Russo Philip L, Leder Karin, Reid Christopher, Billah Baki, Marasco Silvana, McBryde Emma, Richards Michael J
Victorian Hospital Acquired Infection Surveillance System , Melbourne, Victoria, Australia.
Infect Control Hosp Epidemiol. 2007 Oct;28(10):1162-8. doi: 10.1086/519534. Epub 2007 Aug 3.
To analyze the risk factors for surgical site infection (SSI) complicating coronary artery bypass graft (CABG) surgery and to create an alternative SSI risk score based on the results of multivariate analysis.
A prospective cohort study involving inpatient and laboratory-based surveillance of patients who underwent CABG surgery over a 27-month period from January 1, 2003 through March 31, 2005. Data were obtained from 6 acute care hospitals in Victoria, Australia, that contributed surveillance data for SSI complicating CABG surgery to the Victorian Hospital Acquired Infection Surveillance System Coordinating Centre and the Australasian Society of Cardiac and Thoracic Surgeons, also in Victoria.
A total of 4,633 (93%) of the 4,987 patients who underwent CABG surgery during this period were matched in the 2 systems databases. There were 286 SSIs and 62 deep or organ space sternal SSIs (deep or organ space sternal SSI rate, 1.33%). Univariate analysis revealed that diabetes mellitus, body mass index (BMI) greater than 35, and receipt of blood transfusion were risk factors for all types of SSI complicating CABG surgery. Six multivariate analysis models were created to examine either preoperative factors alone or preoperative factors combined with operative factors. All models revealed diabetes and BMI of 30 or greater as risk factors for SSI complicating CABG surgery. A new preoperative scoring system was devised to predict sternal SSI, which assigned 1 point for diabetes, 1 point for BMI of 30 or greater but less than 35, and 2 points for BMI of 35 or greater. Each point in the scoring system represented approximately a doubling of risk of SSI. The new scoring system performed better than the National Nosocomial Infections Surveillance System (NNIS) risk index at predicting SSI.
A new weighted scoring system based on preoperative risk factors was created to predict sternal SSI risk following CABG surgery. The new scoring system outperformed the NNIS risk index. Future studies are needed to validate this scoring system.
分析冠状动脉旁路移植术(CABG)术后手术部位感染(SSI)的危险因素,并根据多变量分析结果创建一个替代的SSI风险评分。
一项前瞻性队列研究,对2003年1月1日至2005年3月31日这27个月期间接受CABG手术的患者进行住院及实验室监测。数据来自澳大利亚维多利亚州的6家急症医院,这些医院将CABG术后发生SSI的监测数据提交给维多利亚州医院获得性感染监测系统协调中心以及同样位于维多利亚州的澳大利亚心脏和胸外科医师协会。
在此期间接受CABG手术的4987例患者中,共有4633例(93%)在两个系统数据库中匹配成功。发生286例SSI,62例深部或器官间隙胸骨SSI(深部或器官间隙胸骨SSI发生率为1.33%)。单变量分析显示,糖尿病、体重指数(BMI)大于35以及接受输血是CABG术后各类SSI的危险因素。创建了6个多变量分析模型,以单独检验术前因素或术前因素与手术因素相结合的情况。所有模型均显示糖尿病和BMI为30或更高是CABG术后发生SSI的危险因素。设计了一种新的术前评分系统来预测胸骨SSI,糖尿病得1分,BMI为30或更高但小于35得1分,BMI为35或更高得2分。评分系统中的每一分大约代表SSI风险增加一倍。新评分系统在预测SSI方面比国家医院感染监测系统(NNIS)风险指数表现更好。
创建了一种基于术前危险因素的新加权评分系统,以预测CABG术后胸骨SSI风险。新评分系统优于NNIS风险指数。未来需要进行研究以验证该评分系统。