Houchin M L, Topp E M
Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas, USA.
J Pharm Sci. 2008 Jul;97(7):2395-404. doi: 10.1002/jps.21176.
Biodegradable poly(lactide-co-glycolide) (PLGA) polymers have been studied extensively for the controlled release of peptide and protein drugs. In addition to polymer biodegradation, chemical degradation of the incorporated peptide/protein has also been reported in PLGA devices, and the role of the polymer in promoting these reactions has been debated. This review summarizes the peptide/protein chemical degradation reactions that have been reported in PLGA systems and their mechanisms. Reported methods for stabilizing peptides and proteins in PLGA devices are also discussed.
可生物降解的聚（丙交酯-共-乙交酯）（PLGA）聚合物已被广泛研究用于肽和蛋白质药物的控释。除了聚合物的生物降解外，在PLGA装置中也有报道称所包封的肽/蛋白质会发生化学降解，并且聚合物在促进这些反应中所起的作用一直存在争议。本综述总结了在PLGA系统中已报道的肽/蛋白质化学降解反应及其机制。还讨论了在PLGA装置中稳定肽和蛋白质的已报道方法。
