硫磷酰胺和磷酰胺对大鼠胃底血管活性肠肽的舒张作用及非肾上腺素能非胆碱能神经元刺激的影响。

Influence of thiorphan and phosphoramidon on the relaxant effect of vasoactive intestinal polypeptide and non-adrenergic non-cholinergic neurone stimulation in the rat gastric fundus.

作者信息

Smits G J, Lefebvre R A

机构信息

Heymans Institute of Pharmacology, University of Gent Medical School, Belgium.

出版信息

Eur J Pharmacol. 1991 Aug 6;200(2-3):361-4. doi: 10.1016/0014-2999(91)90597-j.

DOI:10.1016/0014-2999(91)90597-j

PMID:1782996

Abstract

Relaxations were induced in longitudinal muscle strips of the rat gastric fundus by exogenous administration of vasoactive intestinal polypeptide (VIP) and by transmural stimulation in the presence of atropine. These responses were not influenced by two neutral endopeptidase inhibitors, thiorphan (3 X 10(-5) M) and phosphoramidon (10(-5) M). This suggests that neutral endopeptidase is not involved in the breakdown of exogenous VIP and non-adrenergic non-cholinergic inhibitory transmitters of the rat gastric fundus.

摘要

通过外源给予血管活性肠肽（VIP）以及在阿托品存在的情况下进行跨壁刺激，可诱导大鼠胃底纵行肌条产生舒张反应。这些反应不受两种中性内肽酶抑制剂——硫磷酰胺（3×10⁻⁵ M）和磷酰胺脒（10⁻⁵ M）的影响。这表明中性内肽酶不参与外源VIP以及大鼠胃底非肾上腺素能非胆碱能抑制性递质的分解代谢。