Lee S H, McGregor D H, Kuziez M N
Dis Colon Rectum. 1981 Sep;24(6):462-7. doi: 10.1007/BF02626784.
A case of squamous-cell carcinoma arising in association with perianal condyloma acuminatum was studied by light microscopy. The eight previously reported cases of malignant transformation of perianal and anorectal condylomata acuminatum are reviewed and the salient features described. Light microscopic examination of the case reported here demonstrated several foci of subtle and abrupt transition from condyloma acuminatum to epithelial dysplasia and to carcinoma in situ with focal frank invasion. This study further substantiates the existence of malignant transformation of condyloma acuminatum, particularly in perianal skin.
通过光学显微镜对1例伴发肛周尖锐湿疣的鳞状细胞癌病例进行了研究。对先前报道的8例肛周和肛管尖锐湿疣恶变病例进行了回顾，并描述了其显著特征。对本文报道病例的光学显微镜检查显示，有几个病灶存在从尖锐湿疣到上皮发育异常、原位癌并伴有局灶性明显浸润的细微和突然转变。本研究进一步证实了尖锐湿疣恶变的存在，尤其是在肛周皮肤。
