Morishita S, Shoji M, Oguni Y, Sugimoto C, Hirai Y, Toma S, Ito C
Research Laboratories, Kyushin Pharmaceutical Co., Ltd., Tokyo, Japan.
Nihon Yakurigaku Zasshi. 1991 Dec;98(6):435-42. doi: 10.1254/fpj.98.6_435.
Pharmacological effects of Reiousan, a crude drug preparation consisting of bezoar and ginseng, on experimental cerebral ischemia and anoxia were studied. After administration of Reiousan, the survival time of mice subjected to hypobaric hypoxia and the gasping duration of isolated rat head tended to increase. Reiousan inhibited all the following: lipid peroxides production in rat brain homogenate, tissue swelling induced by the xanthine-xanthine oxidase system in rat brain cortical slices, rat brain swelling induced by freezing, lipid peroxides production in the rat brain after ligation of bilateral common carotid arteries, and lipid peroxides production in Mongolian gerbil brain after reperfusion following ligation of bilateral common carotid arteries. These effects may result from antioxidant activity of bilirubin, a constituent of bezoar.
研究了由牛黄和人参组成的粗药制剂六神丸对实验性脑缺血和缺氧的药理作用。给予六神丸后，低压缺氧小鼠的存活时间和离体大鼠头部的喘息持续时间有增加趋势。六神丸抑制了以下各项：大鼠脑匀浆中脂质过氧化物的产生、大鼠脑皮质切片中黄嘌呤-黄嘌呤氧化酶系统诱导的组织肿胀、冷冻诱导的大鼠脑水肿、双侧颈总动脉结扎后大鼠脑中脂质过氧化物的产生以及双侧颈总动脉结扎后再灌注的蒙古沙土鼠脑中脂质过氧化物的产生。这些作用可能是由于牛黄成分胆红素的抗氧化活性所致。
