Morishita S, Saito T, Shoji M, Tanaka A, Saeki K, Ito C
Research Laboratories, Kyushin Pharmaceutical Co., Ltd., Tokyo, Japan.
Nihon Yakurigaku Zasshi. 1989 Apr;93(4):261-70. doi: 10.1254/fpj.93.261.
Pharmacological effects of Reiousan, a crude drug preparation consisting of bezoar and ginseng, on experimental hepatic injuries and hepatic functions were studied. After administration of Reiousan, carbon tetrachloride, d-galactosamine and alpha-naphthylisothiocyanate-induced experimental hepatic injuries in rats were inhibited. Facilitation of recovery from increased retention rate of sulfobromophthalein in hepatectomized rats, increase in hepatic blood flow, inhibition of superoxide anions, and decrease in blood ethanol concentration in rats administered ethanol were observed after application of Reiousan. Inhibitory effects of Reiousan on experimental hepatic injuries may result from the increase in hepatic blood flow and inhibition of superoxide anions.
研究了由牛黄和人参组成的中药制剂雷奥散对实验性肝损伤和肝功能的药理作用。给予雷奥散后，四氯化碳、d-半乳糖胺和α-萘异硫氰酸酯诱导的大鼠实验性肝损伤受到抑制。应用雷奥散后，观察到肝切除大鼠磺溴酞钠潴留率增加的恢复得到促进、肝血流量增加、超氧阴离子受到抑制以及给予乙醇的大鼠血液乙醇浓度降低。雷奥散对实验性肝损伤的抑制作用可能源于肝血流量的增加和超氧阴离子的抑制。
