Morishita S, Saito T, Shoji M, Hirai Y, Tanaka A
Research Laboratories, Kyushin Pharmaceutical Co., Ltd., Tokyo, Japan.
Nihon Yakurigaku Zasshi. 1988 Mar;91(3):129-40. doi: 10.1254/fpj.91.129.
Pharmacological properties of "Reiousan", a crude drug preparation consisting of bezoar and ginseng, were studied. The hypotensive effect on spontaneously hypertensive rat, inhibition of platelet aggregation, acetic acid-induced writhing, stress ulcer, CCl4 and d-galactosamine-induced hepatic injury, and facilitation of recovery from neuroparalysis and muscular fatigue, protective effect on anoxic brain damages, antipyretic effect, and facilitation of learning in aged mice were observed after administration of "Reiousan". It was suggested that bezoar and ginseng act synergistically in causing the hypotensive effect, acetic acid-induced writhing and drug-induced hepatic injury, and protection from anoxic brain damages and muscular fatigue.
对由牛黄和人参组成的粗制药物制剂“Reiousan”的药理特性进行了研究。给“Reiousan”用药后，观察到其对自发性高血压大鼠的降压作用、对血小板聚集的抑制作用、对醋酸诱导扭体反应的影响、对应激性溃疡的作用、对四氯化碳和d - 半乳糖胺诱导的肝损伤的影响、对神经麻痹和肌肉疲劳恢复的促进作用、对缺氧性脑损伤的保护作用、解热作用以及对老年小鼠学习能力的促进作用。结果表明，牛黄和人参在引起降压作用、醋酸诱导扭体反应及药物诱导肝损伤以及预防缺氧性脑损伤和肌肉疲劳方面具有协同作用。
