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一个GM表型呈现异常分离的日本家庭:一个GM沉默等位基因?

A Japanese family with unusual segregation of GM phenotype: a GM silent allele?

作者信息

Kishida T, Tamaki Y, Wakasugi C

机构信息

Department of Forensic Medicine, Medical College of Oita, Japan.

出版信息

Hum Hered. 1991;41(4):227-30. doi: 10.1159/000154006.

DOI:10.1159/000154006
PMID:1783410
Abstract

A Japanese family with unusual segregation of GM phenotype was found in connection with a case of disputed paternity. Typing for 27 hemogenetic marker systems revealed apparent nonmaternity in the GM system alone. When tested for 14 GM allotypes, the alleged father, the mother, and the child were of the GM A,F,Z N B0,1,3,4,5,S,T,U; GM A,Z N' G,U; and GM A,Z N' B0,3,5,S,T types, respectively. The results of a family study strongly suggested that a GM silent allele was responsible for the apparent nonmaternity; however, definitive evidence could not be obtained.

摘要

在一桩亲子鉴定纠纷案件中,发现了一个GM血型表型呈现异常分离的日裔家庭。对27个血液遗传标记系统进行分型后发现,仅在GM系统中出现了明显的非母系遗传现象。在检测14种GM同种异型时,所谓的父亲、母亲和孩子的GM血型分别为A,F,Z N B0,1,3,4,5,S,T,U;GM A,Z N' G,U;以及GM A,Z N' B0,3,5,S,T型。一项家系研究结果强烈表明,一个GM沉默等位基因是导致明显非母系遗传现象的原因;然而,未能获得确凿证据。

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