Jeremic B, Djuric L, Mijatovic L
KBC Kragujevac, Department of Oncology, Yugoslavia.
Invest New Drugs. 1991 Aug;9(3):277-80. doi: 10.1007/BF00176984.
Eighteen patients with disseminated malignant melanoma were treated with a combination of carboplatinum and cytosine arabinoside. There were 14 males and 4 females with median age of 51 years (range 36-68 years). We observed 4 complete responses (CR) and 3 partial responses (PR). Lung metastases, cutaneous and subcutaneous metastases responded more often, while liver and lymph node metastases did not respond. Two groups of toxicities were observed: gastrointestinal and hematological. Only nine grade 3 toxicities were observed. Response rates and low toxicity we observed during this study warrant its use for patients with disseminated malignant melanoma comparing it in a future studies with DTIC containing regimens.
18例播散性恶性黑色素瘤患者接受了卡铂和阿糖胞苷联合治疗。其中男性14例，女性4例，中位年龄51岁（范围36 - 68岁）。我们观察到4例完全缓解（CR）和3例部分缓解（PR）。肺转移、皮肤及皮下转移的缓解更为常见，而肝转移和淋巴结转移无缓解。观察到两组毒性反应：胃肠道毒性和血液学毒性。仅观察到9例3级毒性反应。我们在本研究中观察到的缓解率和低毒性表明，与未来含达卡巴嗪方案的研究相比，该方案适用于播散性恶性黑色素瘤患者。
