Mulder N H, Sleijfer D T, de Vries E G, Schraffordt Koops H, Willemse P H
Department of Internal Medicine, University Hospital Groningen, The Netherlands.
J Cancer Res Clin Oncol. 1990;116(3):301-2. doi: 10.1007/BF01612907.
Twenty-one patients with disseminated malignant melanoma were treated with a combination of carboplatin and cytosine arabinoside. Two complete and three partial remissions occurred. No complete cross-resistance was found with a regimen containing 5-(dimethyltriazeno)imidazole-4-carboxamide (DTIC) in two patients. It is suggested that this regimen might be studied further as a second-line treatment for patients who fail on DTIC-containing treatment.
21例播散性恶性黑色素瘤患者接受了卡铂和阿糖胞苷联合治疗。出现了2例完全缓解和3例部分缓解。在2例患者中，含5-(二甲基三氮烯)咪唑-4-甲酰胺（DTIC）的方案未发现完全交叉耐药。建议对含DTIC治疗失败的患者，将该方案作为二线治疗进行进一步研究。
