Yoder L J, Guitrau M, Jacobson R
Gillis W Long Hansen's Disease Center, Carville, LA 70721.
Indian J Lepr. 1991 Apr-Jun;63(2):195-202.
Irregular drug intake has been a concern of leprosy control programmes for many years and various methods have been used to monitor and encourage patient compliance. This study compares the results of a urine spot test for dapsone as proposed by Huikeshoven, with blood levels measured in the same patients by the modified Bratton Marshall method and by high performance liquid chromatography. Two hundred-sixty urine and blood specimens were obtained from subjects who were taking supervised and unsupervised medications as well as from controls who were taking no medications. The results indicate that the urine spot test is simple and easily performed, and for monitoring patient compliance under routine clinical conditions (hospital or field work) it compares favourably with blood levels of dapsone estimated by the Bratton Marshall method or by high performance liquid chromatography. The study also shows that dapsone level is not a good indicator of compliance in patients who are also taking daily rifampicin but the urine spot test remains useful in such patients.
多年来，不规则服药一直是麻风病控制项目所关注的问题，人们采用了各种方法来监测并鼓励患者坚持服药。本研究将Huikeshoven提议的氨苯砜尿液即时检测结果，与采用改良的Bratton Marshall法及高效液相色谱法测定的同一批患者的血药浓度进行了比较。从正在接受督导服药和非督导服药的受试者以及未服药的对照组中获取了260份尿液和血液样本。结果表明，尿液即时检测操作简单，在常规临床条件下（医院或现场工作）用于监测患者的服药依从性时，与通过Bratton Marshall法或高效液相色谱法测定的氨苯砜血药浓度相比具有优势。该研究还表明，对于同时每日服用利福平的患者，氨苯砜血药浓度并非服药依从性的良好指标，但尿液即时检测在这类患者中仍然有用。
