De Clercq E, Holý A, Rosenberg I, Sakuma T, Balzarini J, Maudgal P C
Nature. 1986;323(6087):464-7. doi: 10.1038/323464a0.
A new compound has been found, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine ((S)-HPMPA), that has potent and selective activity against a broad spectrum of DNA viruses, including herpes simplex virus (types 1 and 2); varicella zoster virus; thymidine kinase-deficient (TK-) mutants of herpes simplex and varicella zoster virus; human cytomegalovirus; phocid, simian, suid, bovid and equid herpesviruses; African swine fever virus; vaccinia virus; and human adenoviruses. It is also active against retroviruses. We also report that, in mice and rabbits in vivo, the compound is effective against both local and systemic infections with herpes simplex virus type 1, including herpetic keratitis caused by a TK- mutant which is resistant to the classical anti-herpes drugs.
已发现一种新化合物，即（S）-9-（3-羟基-2-膦酰甲氧基丙基）腺嘌呤（（S）-HPMPA），它对多种DNA病毒具有强效且选择性的活性，包括单纯疱疹病毒（1型和2型）；水痘带状疱疹病毒；单纯疱疹病毒和水痘带状疱疹病毒的胸苷激酶缺陷型（TK-）突变体；人巨细胞病毒；海豹、猿猴、猪、牛和马的疱疹病毒；非洲猪瘟病毒；痘苗病毒；以及人腺病毒。它对逆转录病毒也有活性。我们还报告称，在小鼠和兔子体内，该化合物对1型单纯疱疹病毒的局部和全身感染均有效，包括由对经典抗疱疹药物耐药的TK-突变体引起的疱疹性角膜炎。
