青霉素晶体与人体血浆蛋白的相互作用。
INTERACTION BETWEEN CRYSTALLINE PENICILLIN AND HUMAN PLASMA PROTEINS.
出版信息
Science. 1945 Jan 19;101(2612):67-8. doi: 10.1126/science.101.2612.67.
PMID:17840922
Abstract
Penicillin combines with human serum albumin, as demonstrated by dialysis experiments. Unlike the sulfonamfide-albumin complex, the penicillin-albumin possesses antibiotic activity. Such a complex can be freed of unbound penicillin by repeated precipitation at 50 per cent. alcohol and obtained as a dried powder. Mouse excretion studies indicated that the penicillin-albumin complex was excreted more slowly than the sodium salt of penicillin.
摘要
青霉素与人血清白蛋白结合，这可通过透析实验证明。与磺胺-白蛋白复合物不同，青霉素-白蛋白具有抗生素活性。通过在 50%酒精中反复沉淀，可以将这种复合物从未结合的青霉素中分离出来，并得到干粉。小鼠排泄研究表明，与青霉素的钠盐相比，青霉素-白蛋白复合物的排泄速度更慢。
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