Oikarinen J, Mannermaa R M, Tarkka T, Yli-Mäyry N, Majamaa K
Collagen Research Unit, University of Oulu, Finland.
Neurosci Lett. 1991 Nov 11;132(2):171-4. doi: 10.1016/0304-3940(91)90294-4.
We demonstrate here that the H2PO4- analogue AlF4- binds to the nucleotide-binding site of rat liver histone H1 in vitro, and interferes with nucleotide recognition and H1 DNA binding. AlF4- may thus compromise the genetically determined pattern of protein synthesis through binding to H1, the general repressor. The present findings are of interest as a number of studies have implicated aluminium as a factor in the pathogenesis of Alzheimer's disease.
我们在此证明，H2PO4-类似物AlF4-在体外与大鼠肝脏组蛋白H1的核苷酸结合位点结合，并干扰核苷酸识别和H1与DNA的结合。因此，AlF4-可能通过与通用阻遏物H1结合而损害蛋白质合成的遗传决定模式。由于许多研究表明铝是阿尔茨海默病发病机制中的一个因素，所以目前的研究结果很有意义。
