Biurrun O, Ferrer J P, Lorente J, De España R, Gomis R, Traserra J
Department of Otolaryngology, Hospital Clínic i Provincial, University of Barcelona, Spain.
ORL J Otorhinolaryngol Relat Spec. 1991;53(6):335-8. doi: 10.1159/000276242.
Only a few studies have investigated vestibular function in diabetes mellitus (DM), showing contradictory results. We have performed an electronystagmographic (ENG) evaluation of 46 individuals with type I DM and 37 healthy controls. No patient reported subjective vestibular symptoms. Duration of caloric-induced nystagmus (DN) was significantly lower (2.1 +/- 0.7 vs. 2.6 +/- 0.4 min, p less than 0.01), and central nystagmus frequency of caloric response also nonsignificantly tended to be decreased (37.4 +/- 16.5 vs. 41.7 +/- 12.7 beats/30s, p = 0.21) in DM patients, as compared to controls. The latter comparison achieved significance after exclusion of newly diagnosed diabetic patients (33.4 +/- 16.1 vs. 41.6 +/- 12.7 beats/s, p less than 0.05). Depressed caloric reactions were seen in 21.8% of patients. DN was lower in patients with microalbuminuria and retinopathy, but this was not observed after exclusion of newly diagnosed diabetic patients, all of whom had normal ENG responses and no chronic diabetic complications. The existence of a lower DN and central nystagmus frequency should be borne in mind when interpreting ENG tracings in patients with long duration type I diabetes mellitus.
仅有少数研究对糖尿病（DM）患者的前庭功能进行了调查，结果相互矛盾。我们对46例1型糖尿病患者和37名健康对照者进行了眼震电图（ENG）评估。没有患者报告主观前庭症状。与对照组相比，糖尿病患者的冷热试验诱发眼震（DN）持续时间显著缩短（2.1±0.7分钟对2.6±0.4分钟，p<0.01），冷热反应的中枢性眼震频率也有非显著性降低趋势（37.4±16.5次/30秒对41.7±12.7次/30秒，p = 0.21）。在排除新诊断的糖尿病患者后，后一项比较有统计学意义（33.4±16.1次/秒对41.6±12.7次/秒，p<0.05）。21.8%的患者出现冷热反应降低。微量白蛋白尿和视网膜病变患者的DN较低，但在排除新诊断的糖尿病患者后未观察到这种情况，所有这些患者的ENG反应均正常且无慢性糖尿病并发症。在解读病程较长的1型糖尿病患者的ENG描记图时，应牢记存在较低的DN和中枢性眼震频率。
