Craita Cotinica, Didier Charles, Vogel Pierre
Institute of Pharmaceutical Sciences, ETH Zürich, Wolfgang-Pauli-Strasse 10, CH, 8093 Zürich, Switzerland.
Chem Commun (Camb). 2007 Jun 21(23):2411-3. doi: 10.1039/b701293d.
Starting from (E,E)-1-[(1R)-(phenylethyl)oxy]-2-methylpenta-1,3-diene and triethylsilyl enol ether of butanone rapid access to Koert's advanced C10-C28 polyketide fragment of apoptolidin A is now possible.
从(E,E)-1-[(1R)-(苯乙基)氧基]-2-甲基-1,3-戊二烯和丁酮的三乙基硅烯醇醚出发,现在能够快速合成凋亡诱导素A中Koert的高级C10 - C28聚酮片段。