凋亡霉素 E 和 F，新型糖基化大环内酯类化合物，分离自诺卡氏放线菌。
Apoptolidins E and F, new glycosylated macrolactones isolated from Nocardiopsis sp.
机构信息
Department of Chemistry and Department of Chemical and Systems Biology, Stanford University, Stanford, California 94305-5080, USA.
出版信息
Org Lett. 2009 Dec 3;11(23):5474-7. doi: 10.1021/ol902308v.
Abstract
Two new glycosylated macrolactones, apoptolidins E (5) and F (6), were isolated from fermentation of the actinomycete Nocardiopsis sp. and their structures assigned. Lacking the C16 and C20 oxygens of apoptolidin A (1), these macrolides are also the first members of this family to display a 4-O-methyl-l-rhamnose at C9 rather than a 6-deoxy-4-O-methyl-l-glucose.
摘要
两种新的糖基化大环内酯，凋亡素 E（5）和 F（6），从放线菌诺卡氏菌的发酵中分离得到，并确定了它们的结构。与凋亡素 A（1）缺少 C16 和 C20 氧原子不同，这些大环内酯也是该家族中第一个在 C9 位显示 4-O-甲基-l-鼠李糖而不是 6-去氧-4-O-甲基-l-葡萄糖的成员。
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