Dai Sheng-Jun, Peng Wei-Bing, Zhang De-Wu, Shen Li, Wang Wen-Yan, Ren Yan
School of Pharmaceutical Science, Yantai University, Yantai 264005, People's Republic of China.
J Nat Prod. 2009 Oct;72(10):1793-7. doi: 10.1021/np900362z.
Six new neo-clerodane diterpenoid alkaloids, named scutehenanines A-D (1, 4, 5, 6), 6-O-acetylscutehenanine A (2), and 6-O-(2-carbonyl-3-methylbutanoyl)scutehenanine A (3), were isolated from the whole plant of Scutellaria barbata. Their structures were established on the basis of detailed physical data analyses. In vitro, the six new isolated compounds showed cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells) and gave IC50 values in the range 2.8-6.4 microM.
从半枝莲全草中分离得到6个新的新克罗烷二萜生物碱，分别命名为半枝莲碱A - D（1、4、5、6）、6 - O - 乙酰基半枝莲碱A（2）和6 - O -（2 - 羰基 - 3 - 甲基丁酰基）半枝莲碱A（3）。通过详细的物理数据分析确定了它们的结构。体外实验中，这6个新分离的化合物对3种人类癌细胞系（HONE - 1鼻咽癌细胞、KB口腔表皮样癌细胞和HT29结肠癌细胞）显示出细胞毒性活性，IC50值在2.8 - 6.4微摩尔范围内。
