毛茛铁线莲茎中的三萜皂苷。

Triterpenoid saponins from the stems of Clematis parviloba.

作者信息

Yan Li-Hua, Xu Li-Zhen, Lin Jia, Yang Shi-Lin, Feng Yu-Lin

机构信息

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

出版信息

J Asian Nat Prod Res. 2009;11(4):332-8. doi: 10.1080/10286020902727348.

DOI:10.1080/10286020902727348

PMID:19431013

Abstract

Sixteen triterpenoid saponins (1-16) were isolated from the stems of Clematis parviloba, including a new compound, parvilobaside A (1), which was established as 23-O-acetyl-hederagenin-3-O-beta-D-ribopyranosyl-(1 --> 3)-alpha-L-rhamnopyranosyl-(1 --> 2)-alpha-l-arabinopyranoside on the basis of various spectroscopic techniques and chemical evidences. Among the isolated compounds, clematoside S (2) and alpha-hederin (4) showed moderate cytotoxic activities against four human tumor cell lines (HCT-8, Bel-7402, BGC-823, and A-2780) with IC(50) values in the range of 1.44-6.86 microg/ml.

摘要

从毛茛铁线莲茎中分离得到16个三萜皂苷（1 - 16），其中包括一个新化合物，常春藤皂苷元A（1），通过各种光谱技术和化学证据确定其结构为23 - O - 乙酰基 - 常春藤皂苷元 - 3 - O - β - D - 吡喃核糖基 -（1→3）- α - L - 吡喃鼠李糖基 -（1→2）- α - L - 吡喃阿拉伯糖苷。在分离得到的化合物中，铁线莲皂苷S（2）和α - 常春藤皂苷（4）对四种人类肿瘤细胞系（HCT - 8、Bel - 7402、BGC - 823和A - 2780）显示出中等细胞毒性活性，IC50值在1.44 - 6.86μg/ml范围内。