Wilfley Denise E, Tibbs Tiffany L, Van Buren Dorothy J, Reach Kelle P, Walker Mark S, Epstein Leonard H
Department of Psychiatry, Washington University School of Medicine, MO 63110, USA.
Health Psychol. 2007 Sep;26(5):521-32. doi: 10.1037/0278-6133.26.5.521.
Evaluating the efficacy of pediatric weight loss treatments is critical.
This is the first meta-analysis of the efficacy of RCTs comparing pediatric lifestyle interventions to no-treatment or information/education-only controls.
Medline, PsycINFO, and Cochrane Controlled Trials Register.
Fourteen RCTs targetting change in weight status were eligible, yielding 19 effect sizes.
Standardized coding was used to extract information on design, participant characteristics, interventions, and results.
For trials with no-treatment controls, the mean effect size was 0.75 (k = 9, 95% confidence interval [CI] = 0.52-0.98) at end of treatment and 0.60 (k = 4, CI = 0.27-0.94) at follow-up. For trials with information/education-only controls, the mean ES was 0.48 (k = 4, CI = 0.13-0.82) at end of treatment and 0.91 (k = 2, CI = 0.32-1.50) at follow-up. No moderator effects were identified.
Lifestyle interventions for pediatric overweight are efficacious in the short term with some evidence for extended persistence. Future research is required to identify moderators and mediators and to determine the optimal length and intensity of treatment required to produce enduring changes in weight status.
评估儿童减肥治疗的疗效至关重要。
这是第一项对比较儿童生活方式干预与无治疗或仅提供信息/教育对照的随机对照试验疗效的荟萃分析。
医学期刊数据库、心理学文摘数据库和考科蓝对照试验注册库。
14项针对体重状况变化的随机对照试验符合条件,得出19个效应量。
采用标准化编码提取有关设计、参与者特征、干预措施和结果的信息。
对于有未治疗对照组的试验,治疗结束时平均效应量为0.75(k = 9,95%置信区间[CI]=0.52 - 0.98),随访时为0.60(k = 4,CI = 0.27 - 0.94)。对于仅有信息/教育对照组的试验,治疗结束时平均效应量为0.48(k = 4,CI = 0.13 - 0.82),随访时为0.91(k = 2,CI = 0.32 - 1.50)。未发现调节效应。
儿童超重的生活方式干预在短期内有效,并有一些证据表明效果具有持续性。未来需要开展研究以确定调节因素和中介因素,并确定实现体重状况持久改变所需的最佳治疗时长和强度。