Fonder Margaret A, Mamelak Adam J, Kazin Rebecca A, Cohen Bernard A
Department of Dermatology, Johns Hopkins University, Baltimore, Maryland 21287, USA.
Pediatr Dermatol. 2007 Jul-Aug;24(4):376-9. doi: 10.1111/j.1525-1470.2007.00453.x.
Port-wine stains are congenital vascular malformations affecting 0.3% to 0.5% of infants. Dermatitis occurring exclusively or most severely within port-wine stains has been described in the literature. Traditionally, topical corticosteroid therapy has been used for the treatment of dermatitis, while pulseddye laser treatment is considered a safe and effective means of lightening the appearance of congenital port-wine stains. To describe the development of port-wine stain-associated dermatitis as well as a rational treatment approach to these patients, we studied three children with facial, limb, or truncal port-wine stains who developed dermatitis within the congenital vascular malformation either prior to or during treatment with pulseddye laser. Laser therapy of dermatitis-affected areas was subsequently deferred pending resolution of the dermatitis with topical corticosteroid or topical calcineurin inhibitor treatment. While pulseddye laser therapy is an effective means of lightening port-wine stains and achieving lasting resolution of any associated dermatitis, this therapy to dermatitis-affected areas should be postponed until the inflammation resolves to minimize the risk of laser-associated adverse effects.
葡萄酒色斑是一种先天性血管畸形，影响0.3%至0.5%的婴儿。文献中已描述了仅在葡萄酒色斑内或在葡萄酒色斑内最为严重的皮炎。传统上，局部使用皮质类固醇疗法用于治疗皮炎，而脉冲染料激光治疗被认为是减轻先天性葡萄酒色斑外观的一种安全有效的方法。为了描述葡萄酒色斑相关皮炎的发展以及对这些患者合理的治疗方法，我们研究了三名患有面部、肢体或躯干葡萄酒色斑的儿童，他们在脉冲染料激光治疗之前或治疗期间在先天性血管畸形内发生了皮炎。随后，在使用局部皮质类固醇或局部钙调神经磷酸酶抑制剂治疗使皮炎消退之前，推迟对受皮炎影响区域的激光治疗。虽然脉冲染料激光疗法是减轻葡萄酒色斑并实现任何相关皮炎持久消退的有效方法，但对受皮炎影响区域的这种治疗应推迟到炎症消退，以尽量减少激光相关不良反应的风险。
