Mank A P, Ward J P, van Dorp D A
Chem Phys Lipids. 1976 Mar;16(2):107-14. doi: 10.1016/0009-3084(76)90002-5.
A flexible method for synthesising 1,30diflycerides and triglycerides is described. Glycidol esters, prepared by a known route from epichlorohydrin and the sodium salt of a fatty acid, were heated with another or with the same fatty acid and a quaternary ammonium salt. This resulted in a fast, mild reaction and higher yields and greater purity of the diglycerides than hitherto obtained in this synthesis. The mixture of 1,3- and 1,2-diglycerides obtained was isomerised by heating while still in the solid phase to 1,3-diglycerides. Triglycerides were prepared from the diglycerides by acylation using a fatty acid chloride and pyridine in hexane.
描述了一种合成1,3 - 二甘油酯和甘油三酯的灵活方法。由环氧氯丙烷和脂肪酸钠盐通过已知路线制备的缩水甘油酯，与另一种脂肪酸或相同的脂肪酸以及季铵盐一起加热。这导致了快速、温和的反应，并且与迄今该合成中所获得的相比，二甘油酯的产率更高、纯度更高。所获得的1,3 - 和1,2 - 二甘油酯的混合物在仍处于固相时通过加热异构化为1,3 - 二甘油酯。甘油三酯由二甘油酯通过在己烷中使用脂肪酸酰氯和吡啶进行酰化反应制备。
