水合氯醛对长吻大鼠和白化大鼠的不同作用是由于色素沉着还是品系差异？

Are the differential effects of chloral hydrate on hooded rats vs. albino rats due to pigmentation or strain differences?

作者信息

Sisson D F, Siegel J, Westenberg I S

机构信息

Interdisciplinary Graduate Program in Neuroscience, University of Delaware, Newark 19716.

出版信息

Pharmacol Biochem Behav. 1991 Jul;39(3):665-70. doi: 10.1016/0091-3057(91)90144-q.

DOI:10.1016/0091-3057(91)90144-q

PMID:1784595

Abstract

Effects of chloral hydrate anesthesia on EEG power spectra and VEP components were examined as a function of both pigmentation and strain differences in rats. Ten albino Westenberg Long Evans rats (WLE A) were compared to ten pigmented Westenberg Long Evans rats (WLE P), and to ten Wistar albino (Wis A) rats. Albino rats required less chloral hydrate to reach a deep level of anesthesia than pigmented rats. Wistar rats remained anesthetized longer than WLE rats. During deep levels of anesthesia, the lowest EEG frequency band contained more power in Wistar rats than in WLE rats. During moderate levels of anesthesia, frequencies less than 4 Hz lost power while frequencies greater than 13 Hz gained across all rats. Wistar rats had more power in the frequencies less than 8 Hz than did WLE rats; pigmented rats had more power in the frequencies greater than 13 Hz than did albinos. VEP component latencies of pigmented rats were shorter than albinos. Component amplitudes were not significantly different between groups.

摘要

研究了水合氯醛麻醉对大鼠脑电图功率谱和视觉诱发电位成分的影响，并将其作为大鼠色素沉着和品系差异的函数进行考察。将十只白化西滕贝格长 Evans 大鼠（WLE A）与十只有色西滕贝格长 Evans 大鼠（WLE P）以及十只 Wistar 白化大鼠（Wis A）进行比较。与有色大鼠相比，白化大鼠达到深度麻醉所需的水合氯醛更少。Wistar 大鼠的麻醉时间比 WLE 大鼠更长。在深度麻醉期间，Wistar 大鼠最低脑电图频段的功率比 WLE 大鼠更高。在中度麻醉期间，所有大鼠中低于 4 Hz 的频率功率降低，而高于 13 Hz 的频率功率增加。Wistar 大鼠低于 8 Hz 频率的功率比 WLE 大鼠更高；有色大鼠高于 13 Hz 频率的功率比白化大鼠更高。有色大鼠的视觉诱发电位成分潜伏期比白化大鼠短。各组之间成分振幅无显著差异。