中国结核分枝杆菌临床分离株中embB突变与乙胺丁醇最低抑菌浓度之间缺乏相关性。
Lack of correlation between embB mutation and ethambutol MIC in Mycobacterium tuberculosis clinical isolates from China.
作者信息
Shi Ruiru, Zhang Jianyuan, Otomo Koji, Zhang Guolong, Sugawara Isamu
机构信息
Mycobacterial Reference Center, The Research Institute of Tuberculosis, 3-1-24 Matsuyama, Kiyose, Tokyo, Japan.
出版信息
Antimicrob Agents Chemother. 2007 Dec;51(12):4515-7. doi: 10.1128/AAC.00416-07. Epub 2007 Sep 10.
Abstract
Seventy-four Mycobacterium tuberculosis clinical isolates from China were subjected to drug susceptibility testing using ethambutol, isoniazid, rifampin, and ofloxacin. The results revealed that the presence of embB mutations did not correlate with ethambutol resistance but was associated with multiple-drug resistance, especially resistance to both ethambutol and rifampin.
摘要
来自中国的74株结核分枝杆菌临床分离株接受了乙胺丁醇、异烟肼、利福平和氧氟沙星的药敏试验。结果显示，embB基因突变的存在与乙胺丁醇耐药性无关，但与多重耐药相关，尤其是对乙胺丁醇和利福平均耐药。
相似文献
1
Lack of correlation between embB mutation and ethambutol MIC in Mycobacterium tuberculosis clinical isolates from China.中国结核分枝杆菌临床分离株中embB突变与乙胺丁醇最低抑菌浓度之间缺乏相关性。
Antimicrob Agents Chemother. 2007 Dec;51(12):4515-7. doi: 10.1128/AAC.00416-07. Epub 2007 Sep 10.
2
Frequency of embB codon 306 mutations in ethambutol-susceptible and -resistant clinical Mycobacterium tuberculosis isolates in Kuwait.科威特易感性和耐药性临床结核分枝杆菌分离株中embB基因306密码子突变的频率
Tuberculosis (Edinb). 2007 Mar;87(2):123-9. doi: 10.1016/j.tube.2006.05.004. Epub 2007 Feb 7.
3
Genetic characterisation of the ethambutol resistance-determining region in Mycobacterium tuberculosis: prevalence and significance of embB306 mutations.结核分枝杆菌中乙胺丁醇耐药决定区的基因特征：embB306突变的流行情况及意义
Int J Antimicrob Agents. 2009 Apr;33(4):334-8. doi: 10.1016/j.ijantimicag.2008.09.021. Epub 2008 Dec 18.
4
Simultaneous detection of isoniazid, rifampin, and ethambutol resistance of Mycobacterium tuberculosis by a single multiplex allele-specific polymerase chain reaction (PCR) assay.通过单一多重等位基因特异性聚合酶链反应（PCR）检测法同时检测结核分枝杆菌对异烟肼、利福平及乙胺丁醇的耐药性。
Diagn Microbiol Infect Dis. 2005 Nov;53(3):201-8. doi: 10.1016/j.diagmicrobio.2005.06.007. Epub 2005 Oct 21.
5
Evaluation of wild-type MIC distributions as a tool for determination of clinical breakpoints for Mycobacterium tuberculosis.评估野生型最低抑菌浓度分布作为确定结核分枝杆菌临床断点的工具。
J Antimicrob Chemother. 2009 Oct;64(4):786-93. doi: 10.1093/jac/dkp262. Epub 2009 Jul 23.
6
Characteristics of embB mutations in multidrug-resistant Mycobacterium tuberculosis isolates in Henan, China.中国河南地区耐多药结核分枝杆菌分离株中 embB 基因突变特征。
J Antimicrob Chemother. 2011 Oct;66(10):2240-7. doi: 10.1093/jac/dkr284. Epub 2011 Jul 21.
7
embCAB sequence variation among ethambutol-resistant Mycobacterium tuberculosis isolates without embB306 mutation.耐乙胺丁醇结核分枝杆菌分离株中 embCAB 序列变异而无 embB306 突变。
J Antimicrob Chemother. 2010 Jul;65(7):1359-67. doi: 10.1093/jac/dkq120. Epub 2010 Apr 28.
8
Detection of mutations associated with multidrug-resistant Mycobacterium tuberculosis clinical isolates.耐多药结核分枝杆菌临床分离株相关突变的检测
FEMS Immunol Med Microbiol. 2011 Aug;62(3):321-7. doi: 10.1111/j.1574-695X.2011.00814.x. Epub 2011 Jun 9.
9
Development of a pyrosequencing approach for rapid screening of rifampin, isoniazid and ethambutol-resistant Mycobacterium tuberculosis.一种用于快速筛查耐利福平、异烟肼和乙胺丁醇结核分枝杆菌的焦磷酸测序方法的开发。
Int J Tuberc Lung Dis. 2005 Mar;9(3):328-32.
10
Role of embCAB gene mutations in ethambutol resistance in Mycobacterium tuberculosis isolates from India.embCAB基因突变在印度结核分枝杆菌分离株乙胺丁醇耐药性中的作用。
Int J Antimicrob Agents. 2009 May;33(5):483-6. doi: 10.1016/j.ijantimicag.2008.10.017. Epub 2008 Dec 27.
引用本文的文献
1
Frequency of Codon 306 Mutations in Gene of Resistant to Ethambutol: A Systematic Review and Meta-Analysis.乙胺丁醇耐药基因中密码子306突变的频率：一项系统评价和Meta分析
Int J Prev Med. 2020 Jul 22;11:112. doi: 10.4103/ijpvm.IJPVM_114_19. eCollection 2020.
2
Drug Resistance and Transmission among Human Immunodeficiency Virus-Infected Patients in Ho Chi Minh City, Vietnam.越南胡志明市感染人类免疫缺陷病毒患者的耐药性和传播。
Am J Trop Med Hyg. 2018 Dec;99(6):1397-1406. doi: 10.4269/ajtmh.18-0185.
3
Mutations within Are Associated with Variable Level of Ethambutol Resistance in Mycobacterium tuberculosis Isolates from China.中国结核分枝杆菌分离株中 基因突变与乙胺丁醇耐药水平相关。
Antimicrob Agents Chemother. 2017 Dec 21;62(1). doi: 10.1128/AAC.01279-17. Print 2018 Jan.
4
Molecular and Growth-Based Drug Susceptibility Testing of Mycobacterium tuberculosis Complex for Ethambutol Resistance in the United States.美国结核分枝杆菌复合群乙胺丁醇耐药性的分子与基于生长的药敏试验
Tuberc Res Treat. 2016;2016:3404860. doi: 10.1155/2016/3404860. Epub 2016 Jun 8.
5
Genome Analysis of the First Extensively Drug-Resistant (XDR) Mycobacterium tuberculosis in Malaysia Provides Insights into the Genetic Basis of Its Biology and Drug Resistance.马来西亚首例广泛耐药结核分枝杆菌的基因组分析为其生物学特性及耐药性的遗传基础提供了见解。
PLoS One. 2015 Jun 25;10(6):e0131694. doi: 10.1371/journal.pone.0131694. eCollection 2015.
6
Integrated microfluidic card with TaqMan probes and high-resolution melt analysis to detect tuberculosis drug resistance mutations across 10 genes.集成有TaqMan探针和高分辨率熔解分析的微流控芯片，用于检测10个基因的结核耐药性突变
mBio. 2015 Feb 24;6(2):e02273. doi: 10.1128/mBio.02273-14.
7
Analysis of embCAB mutations associated with ethambutol resistance in multidrug-resistant mycobacterium tuberculosis isolates from China.中国耐多药结核分枝杆菌分离株中与乙胺丁醇耐药相关的embCAB基因突变分析。
Antimicrob Agents Chemother. 2015 Apr;59(4):2045-50. doi: 10.1128/AAC.04933-14. Epub 2015 Jan 20.
8
Mutations in the embB gene and their association with ethambutol resistance in multidrug-resistant Mycobacterium tuberculosis clinical isolates from Poland.波兰耐多药结核分枝杆菌临床分离株中embB基因的突变及其与乙胺丁醇耐药性的关联
Biomed Res Int. 2013;2013:167954. doi: 10.1155/2013/167954. Epub 2013 Dec 11.
9
Mycobacterium tuberculosis embB codon 306 mutations confer moderately increased resistance to ethambutol in vitro and in vivo.结核分枝杆菌 embB 密码子 306 突变赋予体外和体内对乙胺丁醇的中度增加耐药性。
Antimicrob Agents Chemother. 2011 Jun;55(6):2891-6. doi: 10.1128/AAC.00007-10. Epub 2011 Mar 28.
10
Delineating bacteriostatic and bactericidal targets in mycobacteria using IPTG inducible antisense expression.利用异丙基-β-D-硫代半乳糖苷（IPTG）诱导的反义表达来确定分枝杆菌中的抑菌和杀菌靶点。
PLoS One. 2009 Jun 15;4(6):e5923. doi: 10.1371/journal.pone.0005923.
本文引用的文献
1
Emergence of ofloxacin resistance in Mycobacterium tuberculosis clinical isolates from China as determined by gyrA mutation analysis using denaturing high-pressure liquid chromatography and DNA sequencing.运用变性高效液相色谱和DNA测序技术通过gyrA突变分析确定中国结核分枝杆菌临床分离株中氧氟沙星耐药性的出现情况
J Clin Microbiol. 2006 Dec;44(12):4566-8. doi: 10.1128/JCM.01916-06. Epub 2006 Oct 11.
2
The molecular epidemiology of ethambutol-resistant Mycobacterium tuberculosis in Henan Province, China.中国河南省耐乙胺丁醇结核分枝杆菌的分子流行病学
Jpn J Infect Dis. 2005 Dec;58(6):393-5.
3
Temperature-mediated heteroduplex analysis for the detection of drug-resistant gene mutations in clinical isolates of Mycobacterium tuberculosis by denaturing HPLC, SURVEYOR nuclease.通过变性高效液相色谱法、SURVEYOR核酸酶进行温度介导的异源双链分析，以检测结核分枝杆菌临床分离株中的耐药基因突变
Microbes Infect. 2006 Jan;8(1):128-35. doi: 10.1016/j.micinf.2005.06.008. Epub 2005 Aug 10.
4
Role of embB codon 306 mutations in Mycobacterium tuberculosis revisited: a novel association with broad drug resistance and IS6110 clustering rather than ethambutol resistance.重新审视embB密码子306突变在结核分枝杆菌中的作用：与广泛耐药和IS6110聚类而非乙胺丁醇耐药的新关联。
Antimicrob Agents Chemother. 2005 Sep;49(9):3794-802. doi: 10.1128/AAC.49.9.3794-3802.2005.
5
Characterisation of rpsL, rrs and embB mutations associated with streptomycin and ethambutol resistance in Mycobacterium tuberculosis.结核分枝杆菌中与链霉素和乙胺丁醇耐药性相关的rpsL、rrs和embB基因突变特征分析
Res Microbiol. 2004 Dec;155(10):830-4. doi: 10.1016/j.resmic.2004.06.007.
6
Novel mutations within the embB gene in ethambutol-susceptible clinical isolates of Mycobacterium tuberculosis.结核分枝杆菌乙胺丁醇敏感临床分离株中embB基因的新型突变
Antimicrob Agents Chemother. 2004 Nov;48(11):4447-9. doi: 10.1128/AAC.48.11.4447-4449.2004.
7
Multicenter evaluation of reverse line blot assay for detection of drug resistance in Mycobacterium tuberculosis clinical isolates.用于检测结核分枝杆菌临床分离株耐药性的反向线杂交分析的多中心评估
J Microbiol Methods. 2004 Jun;57(3):323-35. doi: 10.1016/j.mimet.2004.02.006.
8
Mode of action of ethambutol.乙胺丁醇的作用方式。
J Bacteriol. 1962 Nov;84(5):1099-103. doi: 10.1128/jb.84.5.1099-1103.1962.
9
Detection of embB306 mutations in ethambutol-susceptible clinical isolates of Mycobacterium tuberculosis from Northwestern Russia: implications for genotypic resistance testing.俄罗斯西北部结核分枝杆菌乙胺丁醇敏感临床分离株中embB306突变的检测：对基因型耐药性检测的意义
J Clin Microbiol. 2002 Oct;40(10):3810-3. doi: 10.1128/JCM.40.10.3810-3813.2002.
10
High-resolution minisatellite-based typing as a portable approach to global analysis of Mycobacterium tuberculosis molecular epidemiology.基于高分辨率微卫星的分型作为一种用于结核分枝杆菌分子流行病学全球分析的便捷方法。
Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1901-6. doi: 10.1073/pnas.98.4.1901.
Zotero 插件