Shi Ruiru, Zhang Jianyuan, Otomo Koji, Zhang Guolong, Sugawara Isamu
Mycobacterial Reference Center, The Research Institute of Tuberculosis, 3-1-24 Matsuyama, Kiyose, Tokyo, Japan.
Antimicrob Agents Chemother. 2007 Dec;51(12):4515-7. doi: 10.1128/AAC.00416-07. Epub 2007 Sep 10.
Seventy-four Mycobacterium tuberculosis clinical isolates from China were subjected to drug susceptibility testing using ethambutol, isoniazid, rifampin, and ofloxacin. The results revealed that the presence of embB mutations did not correlate with ethambutol resistance but was associated with multiple-drug resistance, especially resistance to both ethambutol and rifampin.
来自中国的74株结核分枝杆菌临床分离株接受了乙胺丁醇、异烟肼、利福平和氧氟沙星的药敏试验。结果显示,embB基因突变的存在与乙胺丁醇耐药性无关,但与多重耐药相关,尤其是对乙胺丁醇和利福平均耐药。