多国耐药结核分枝杆菌分离株样本中的抗生素耐药性及单核苷酸多态性聚类分组类型
Antibiotic resistance and single-nucleotide polymorphism cluster grouping type in a multinational sample of resistant Mycobacterium tuberculosis isolates.
作者信息
Brimacombe M, Hazbon M, Motiwala A S, Alland D
机构信息
Department of Preventive Medicine and Community Health, New Jersey Medical School-UMDNJ, 185 S. Orange Ave., MSB F-647, Newark, NJ 07083, USA.
出版信息
Antimicrob Agents Chemother. 2007 Nov;51(11):4157-9. doi: 10.1128/AAC.00619-07. Epub 2007 Sep 10.
Abstract
A single-nucleotide polymorphism-based cluster grouping (SCG) classification system for Mycobacterium tuberculosis was used to examine antibiotic resistance type and resistance mutations in relationship to specific evolutionary lineages. Drug resistance and resistance mutations were seen across all SCGs. SCG-2 had higher proportions of katG codon 315 mutations and resistance to four drugs.
摘要
一种基于单核苷酸多态性的结核分枝杆菌聚类分组（SCG）分类系统被用于研究抗生素耐药类型以及与特定进化谱系相关的耐药突变。在所有SCG中均发现了耐药性和耐药突变。SCG-2中katG密码子315突变以及对四种药物耐药的比例更高。
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