Miglioli P A, Pivetta P, Fantoni U, Nodari F
Department of Pharmacology, University of Padua, Italy.
Chemotherapy. 1990;36(5):321-4. doi: 10.1159/000238783.
A study on the effects of the mode of administration on aztreonam (AZ) concentrations in pleural fluid was performed in human subjects. The same dose of AZ was given as an intravenous bolus injection to one group and as a drip infusion to another group of patients. Serum and pleural fluid samples were collected at different times after drug administration, and the antibiotic concentrations were measured by using a microbiological method. The highest serum and pleural exudate concentrations and area under the curve values were obtained after drip infusion. These results indicate that drip infusion gives higher concentrations of AZ in pleural effusion.
在人体受试者中进行了一项关于给药方式对氨曲南（AZ）在胸腔积液中浓度影响的研究。给一组患者静脉推注相同剂量的AZ，给另一组患者静脉滴注相同剂量的AZ。在给药后的不同时间采集血清和胸腔积液样本，并采用微生物学方法测量抗生素浓度。静脉滴注后获得了最高的血清和胸腔渗出液浓度以及曲线下面积值。这些结果表明，静脉滴注使胸腔积液中的AZ浓度更高。
