Park C-H, Ikadai H, Yoshida E, Isomura H, Inukai H, Oyamada T
Department of Veterinary Pathology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada 034-8628, Japan.
Vet Pathol. 2007 Sep;44(5):683-7. doi: 10.1354/vp.44-5-683.
A 16-year-old female Japanese cat was presented with a single mammary-gland nodule approximately 3 cm in diameter. Histologically, the nodule consisted of necrotizing granulomatous panniculitis, vasculitis, and mastitis, and contained free and clustered protozoal organisms. The organism was present in the cytoplasm of macrophages, fibroblasts, endothelial cells, and mammary-gland epithelia. The organism was positive for anti- Toxoplasma gondii and anti- Neospora caninum antibodies. Electron microscopy showed single and grouped tachyzoites, with morphologic features similar to those of T. gondii. Polymerase chain reaction and deoxyribonucleic acid sequence analysis was consistent with T. gondii infection. This is the first report of cutaneous toxoplasmosis in a Japanese cat.
一只16岁的日本雌性猫出现了一个直径约3厘米的乳腺结节。组织学上，该结节由坏死性肉芽肿性脂膜炎、血管炎和乳腺炎组成，并含有游离和聚集的原生动物。该生物体存在于巨噬细胞、成纤维细胞、内皮细胞和乳腺上皮细胞的细胞质中。该生物体对抗弓形虫和抗新孢子虫抗体呈阳性。电子显微镜显示单个和成群的速殖子，其形态特征与弓形虫相似。聚合酶链反应和脱氧核糖核酸序列分析与弓形虫感染一致。这是日本猫皮肤弓形虫病的首例报告。
