Ortín A, Pérez de Villarreal M, Minguijón E, Cousens C, Sharp J M, De las Heras M
Departamento de Patología Animal, Facultad de Veterinaria, University of Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain.
J Comp Pathol. 2004 Nov;131(4):253-8. doi: 10.1016/j.jcpa.2004.04.005.
Ten sheep naturally affected with enzootic nasal adenocarcinoma (ENA), a disease associated with ovine enzootic nasal tumour virus (ENTV-1), were found also to be infected with jaagsiekte sheep retrovirus (JSRV), the causal agent of ovine pulmonary adenocarcinoma (OPA). Only one of the sheep showed OPA lung lesions. The animals belonged to 10 flocks located in a geographical area in which OPA is frequently seen. ENTV-1 was found in all the ENA tumours but only occasionally in extra-tumoral sites, confirming the results of a previous study. In contrast, JSRV had a disseminated tissue distribution, similar to that previously reported for animals infected with JSRV. However, the occurrence of JSRV in lymphoid tissues was clearly greater than in sheep infected with JSRV but with no lesions of ENA. The data suggested a synergistic relationship between ENTV-1 and JSRV, resulting in increased proliferation of JSRV.
十只自然感染地方流行性鼻腺癌（ENA）的绵羊，一种与绵羊地方流行性鼻肿瘤病毒（ENTV-1）相关的疾病，被发现同时感染了绵羊肺腺瘤病毒（JSRV），即绵羊肺腺癌（OPA）的病原体。这些绵羊中只有一只出现了OPA肺部病变。这些动物来自10个位于OPA常见地理区域的羊群。在所有ENA肿瘤中均发现了ENTV-1，但仅偶尔在肿瘤外部位发现，这证实了先前一项研究的结果。相比之下，JSRV具有广泛的组织分布，与先前报道的感染JSRV的动物相似。然而，JSRV在淋巴组织中的出现明显多于感染JSRV但无ENA病变的绵羊。数据表明ENTV-1和JSRV之间存在协同关系，导致JSRV增殖增加。
