Nedić Olgica, Malenković Vesna, Nikolić Judith Anna, Baricević Ivona
Institute for the Application of Nuclear Energy (INEP), University of Belgrade, Belgrade Serbia.
J Clin Lab Anal. 2007;21(5):335-9. doi: 10.1002/jcla.20193.
Gastrointestinal ailments evoke changes in the hypothalamic-pituitary-adrenal (HPA) axis and modulation of hepatic protein synthesis. We examined the catabolic effect of certain primary gastrointestinal diseases and surgery on the concentration of insulin-like growth factor I (IGF-I). Blood samples from patients with gastric cancer (GC), cholecystitis (CC), or inguinal hernia (IH) were taken before and after surgery. The concentrations of IGF-I, IGF binding protein-1 (IGFBP-1), insulin, cortisol, and glucose were determined. In GC patients the concentration of IGF-I was reduced and the concentrations of IGFBP-1 and cortisol were elevated preoperatively; after surgery, IGFBP-1 normalized. In CC patients the concentration of IGF-I was low and the concentration of IGFBP-1 was high before cholecystectomy; after surgery IGFBP-1 returned to normal and the concentration of cortisol increased. In IH patients the concentration of IGF-I was low and the concentrations of IGFBP-1 and cortisol were high before surgery; after laparotomy IGFBP-1 returned to normal. The metabolic changes were present in all analyzed patient groups, regardless of the severity of disease and nutrition. The concentration of IGF-I was reduced before surgery and remained reduced after, recommending IGF-I as a metabolic marker in both pre and postoperative examination of patients.
胃肠道疾病会引起下丘脑 - 垂体 - 肾上腺（HPA）轴的变化以及肝脏蛋白质合成的调节。我们研究了某些原发性胃肠道疾病和手术对胰岛素样生长因子I（IGF - I）浓度的分解代谢作用。在手术前后采集了胃癌（GC）、胆囊炎（CC）或腹股沟疝（IH）患者的血样。测定了IGF - I、IGF结合蛋白 - 1（IGFBP - 1）、胰岛素、皮质醇和葡萄糖的浓度。在GC患者中，术前IGF - I浓度降低，IGFBP - 1和皮质醇浓度升高；手术后，IGFBP - 1恢复正常。在CC患者中，胆囊切除术前IGF - I浓度低，IGFBP - 1浓度高；手术后IGFBP - 1恢复正常，皮质醇浓度升高。在IH患者中，手术前IGF - I浓度低，IGFBP - 1和皮质醇浓度高；剖腹手术后IGFBP - 1恢复正常。所有分析的患者组均出现代谢变化，无论疾病严重程度和营养状况如何。术前IGF - I浓度降低，术后仍保持降低，这表明IGF - I可作为患者术前和术后检查的代谢标志物。
