二硫代氨基甲酸盐对小鼠体内镉排泄和分布影响的效果比较。

Comparison of the effectiveness of dithiocarbamates on the excretion and distribution of cadmium in mice.

作者信息

Shimada H, Funakoshi T, Kiyozumi M, Kojima S

机构信息

Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.

出版信息

Res Commun Chem Pathol Pharmacol. 1991 Aug;73(2):249-52.

PMID:1784839

Abstract

Sodium N-benzyl-D-glucamine dithiocarbamate (BGD), sodium N-p-hydroxymethylbenzyl-D-glucamine dithiocarbamate (HBGD), and sodium N-p-methoxybenzyl-D-glucamine dithiocarbamate (MeOBGD) were evaluated for their efficacy in the distribution and excretion of cadmium in mice exposed to cadmium. Mice were injected i.p. with 109CdCl2 (1 mg Cd/kg and 74 kBq of 109Cd/mouse) and 30 min or 24 h later, they were injected i.p. with chelating agents (5% of an LD50). The results of this study indicated that the injection of HBGD to mice pretreated with cadmium can remove cadmium from the body without redistribution of cadmium to the brain, testes, and heart more effectively than that of BGD or MeOBGD.

摘要

对 N-苄基-D-葡糖胺二硫代氨基甲酸钠（BGD）、N-对羟甲基苄基-D-葡糖胺二硫代氨基甲酸钠（HBGD）和 N-对甲氧基苄基-D-葡糖胺二硫代氨基甲酸钠（MeOBGD）在接触镉的小鼠体内镉的分布和排泄方面的功效进行了评估。给小鼠腹腔注射 109CdCl2（1 毫克镉/千克，每只小鼠 74 千贝克勒尔的 109Cd），30 分钟或 24 小时后，腹腔注射螯合剂（LD50 的 5%）。这项研究结果表明，给预先用镉处理过的小鼠注射 HBGD 比注射 BGD 或 MeOBGD 能更有效地从体内清除镉，且不会使镉重新分布到脑、睾丸和心脏。