Kojima S, Kawagoe M, Kiyozumi M, Shimada H
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Chem Pharm Bull (Tokyo). 1990 Nov;38(11):3136-9. doi: 10.1248/cpb.38.3136.
N-Benzyl-D-glucamine dithiocarbamate (BGD), N-p-hydroxymethylbenzyl-D-glucamine dithiocarbamate (HBGD), and N-p-carboxybenzyl-D-glucamine dithiocarbamate (CBGD) were compared for their relative efficacies in the distribution and excretion of cadmium in mice exposed to cadmium. Mice were injected intraperitoneally with 109CdCl2 (1 mg of Cd/kg and 2 microCi of 109Cd/one animal). Three days later, they were injected with chelating agents (400 mumol/kg) every other day for 2 weeks. After injections of BGD and HBGD, cadmium was excreted mainly in the feces through the bile, and the fecal excretion of cadmium by HBGD was significantly higher than that by BGD or CBGD. These chelating agents increased the urinary excretion of cadmium to a small extent. The hepatic cadmium content was decreased only after HBGD injection. Also, the injection of HBGD caused a much greater decrease in renal cadmium content than did BGD or CBGD. These chelating agents did not result in the redistribution of cadmium to the brain, testes, or heart. The growth of mice was only slightly retarded by injections of these chelating agents. The results of this study indicate that the injection of HBGD to mice pretreated with cadmium can remove cadmium from the body, mainly through fecal excretion, without redistribution of cadmium to other tissues such as the brain, testes, and heart, more effectively than BGD or CBGD.
比较了N-苄基-D-葡糖胺二硫代氨基甲酸盐（BGD）、N-对羟甲基苄基-D-葡糖胺二硫代氨基甲酸盐（HBGD）和N-对羧基苄基-D-葡糖胺二硫代氨基甲酸盐（CBGD）对接触镉的小鼠体内镉分布和排泄的相对效果。给小鼠腹腔注射109CdCl2（1毫克镉/千克体重，每只动物2微居里109Cd）。三天后，每隔一天给它们注射螯合剂（400微摩尔/千克），持续2周。注射BGD和HBGD后，镉主要通过胆汁经粪便排出，HBGD使镉的粪便排泄量显著高于BGD或CBGD。这些螯合剂使镉的尿排泄量略有增加。仅在注射HBGD后肝脏镉含量降低。而且，与BGD或CBGD相比，注射HBGD导致肾脏镉含量下降幅度更大。这些螯合剂不会导致镉重新分布到脑、睾丸或心脏。这些螯合剂的注射仅使小鼠生长略有迟缓。本研究结果表明，给预先接触镉的小鼠注射HBGD能比BGD或CBGD更有效地将镉从体内清除，主要通过粪便排泄，且不会使镉重新分布到脑、睾丸和心脏等其他组织。
