Kiyozumi M, Nouchi T, Honda T, Kojima S, Tsuruoka M
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Toxicology. 1990 Mar 16;60(3):275-85. doi: 10.1016/0300-483x(90)90150-f.
Sodium N-benzyl-D-glucamine dithiocarbamate (BGD), sodium N-p-methylbenzyl-D-glucamine dithiocarbamate (MBGD), and sodium N-p-isopropylbenzyl-D-glucamine dithiocarbamate (PBGD), which were recently synthesized, were evaluated for their efficacy in the distribution and excretion of cadmium in rats and mice exposed to cadmium. Rats and mice were injected i.p. with 109CdCl2 (1 mg Cd/kg and 2 microCi 109Cd/one animal) and 3 days later, they were treated with the dithiocarbamates (400 mumol/kg) every other day for 2 weeks. These dithiocarbamates were effective in removing cadmium from the body without increasing the cadmium content in the kidney. After treatment with BGD, MBGD, and PBGD, cadmium was excreted mainly in the feces and the effect of MBGD and PBGD on the fecal excretion of cadmium was much larger than that of BGD. The treatment with these dithiocarbamates did not cause the redistribution of cadmium to brain, testes, and heart in rats and mice. The treatment of mice with PBGD decreased the concentrations of essential metals in liver, kidney, and brain. The extent of acute toxicity of the dithiocarbamates in mice was in the order PBGD greater than MBGD greater than BGD.
最近合成的N-苄基-D-葡糖胺二硫代氨基甲酸钠（BGD）、N-对甲基苄基-D-葡糖胺二硫代氨基甲酸钠（MBGD）和N-对异丙基苄基-D-葡糖胺二硫代氨基甲酸钠（PBGD），针对其在镉暴露的大鼠和小鼠体内镉的分布及排泄方面的功效进行了评估。给大鼠和小鼠腹腔注射109CdCl2（1毫克镉/千克体重，每只动物2微居里109Cd），3天后，每隔一天用二硫代氨基甲酸盐（400微摩尔/千克体重）处理2周。这些二硫代氨基甲酸盐能有效从体内清除镉，且不会增加肾脏中的镉含量。用BGD、MBGD和PBGD处理后，镉主要通过粪便排出，MBGD和PBGD对镉粪便排泄的作用比BGD大得多。用这些二硫代氨基甲酸盐处理不会导致大鼠和小鼠体内的镉重新分布到脑、睾丸和心脏。用PBGD处理小鼠会降低肝脏、肾脏和脑中必需金属的浓度。二硫代氨基甲酸盐对小鼠的急性毒性程度依次为PBGD大于MBGD大于BGD。
