环磷酰胺渗漏——原发性乳腺癌患者组织坏死病例报告
Paravasation with cyclophosphamide--case report of tissue necrosis in a patient with primary breast cancer.
作者信息
Jueckstock Julia K, Mylonas Ioannis, Strobl Barbara, Willgeroth Fritz, Sommer Harald L, Friese Klaus
机构信息
First Department of Obstetrics and Gynecology, Ludwig-Maximilians University Munich, Germany.
出版信息
Onkologie. 2007 Sep;30(8-9):452-4. doi: 10.1159/000105319. Epub 2007 Sep 7.
BACKGROUND
Paravasation is a rare but severe complication of treatment with cytotoxic agents. Some anticancer drugs are considered to be of high toxicity (vesicant), some are merely irritant, and some are regarded as nearly non-toxic to healthy tissue as is the case with cyclophosphamide.
CASE REPORT
In this report, we present the first case of severe tissue damage caused by a paravasation of cyclophosphamide in a breast cancer patient receiving chemotherapy.
CONCLUSION
Therefore, every attending oncological physician should be aware of the possibility of severe tissue damage as a consequence of cyclophosphamide paravasation.
背景
药物外渗是细胞毒性药物治疗中一种罕见但严重的并发症。一些抗癌药物被认为具有高毒性（发泡剂），一些只是刺激性的，而有些则被视为对健康组织几乎无毒，如环磷酰胺。
病例报告
在本报告中，我们呈现了首例接受化疗的乳腺癌患者因环磷酰胺外渗导致严重组织损伤的病例。
结论
因此，每位主治肿瘤内科医生都应意识到环磷酰胺外渗可能导致严重组织损伤。
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