Erdem N, Erdogan M, Ozbek M, Karadeniz M, Cetinkalp S, Ozgen A Gokhan, Saygili F, Yilmaz C, Tuzun M, Kabalak T
Department of Internal Medicine, Faculty of Medicine, Ege University, Izmir, Turkey.
J Endocrinol Invest. 2007 Jul-Aug;30(7):546-50. doi: 10.1007/BF03346347.
Turkey is an endemic area for thyroid diseases. The Aegean region is well documented for increased prevalence of thyroid disorders. In this study we investigated the demographic and clinical features of subacute thyroiditis (SAT) patients who had been diagnosed and treated in Ege University.
The hospital files of patients admitted to the endocrinology clinic of Ege University between January 1987 and December 2001 were retrospectively evaluated. Patients who had been diagnosed as having any thyroid disorder were determined.
176 fulfilled diagnostic criteria for SAT. The majority of patients with SAT were diagnosed as having subacute granulomatous thyroiditis (169/176) (134 females, 35 males, mean age 34.0+/-17.8 yr); 69% of the patients were between 30-50 yr of age. Thyroid pain was present in 97.1% of female patients, and in 100% of male patients. High fever was evident in 78 patients (46.2%). Mean erythrocyte sedimentation rate (ESR) was 43.42+/-39.68 mm/h. Anti-thyroglobulin antibody was positive in 20%, and anti-thyroid peroxydase antibody was positive in 4% of patients. Among patients who were treated with non-steroidal anti-inflammatory drugs (NSAD) 10 female patients (10.6%), and 3 male patients (12%) developed recurrence of the disease. Among patients who were treated with prednisolone 7 female patients (17.5%), and one male patient (10%) developed recurrence. There was no significant difference regarding the recurrence rates between patients who were treated with NSAD and patients who were treated with prednisolone.
With the exception of ESR, demographic, clinical, laboratory, and imaging findings and prognoses of our patients were comparable to the previous reports.
土耳其是甲状腺疾病的流行地区。爱琴海地区甲状腺疾病患病率增加已有充分记录。在本研究中，我们调查了在伊兹密尔大学诊断和治疗的亚急性甲状腺炎（SAT）患者的人口统计学和临床特征。
回顾性评估1987年1月至2001年12月期间入住伊兹密尔大学内分泌科门诊患者的医院档案。确定诊断患有任何甲状腺疾病的患者。
176例符合SAT诊断标准。大多数SAT患者被诊断为亚急性肉芽肿性甲状腺炎（169/176）（女性134例，男性35例，平均年龄34.0±17.8岁）；69%的患者年龄在30至50岁之间。97.1%的女性患者和100%的男性患者出现甲状腺疼痛。78例患者（46.2%）有高热。平均红细胞沉降率（ESR）为43.42±39.68mm/h。20%的患者抗甲状腺球蛋白抗体呈阳性，4%的患者抗甲状腺过氧化物酶抗体呈阳性。在接受非甾体抗炎药（NSAD）治疗的患者中，10例女性患者（10.6%）和3例男性患者（12%）疾病复发。在接受泼尼松龙治疗的患者中，7例女性患者（17.5%）和1例男性患者（10%）疾病复发。接受NSAD治疗的患者与接受泼尼松龙治疗的患者之间的复发率无显著差异。
除ESR外，我们患者的人口统计学、临床、实验室和影像学检查结果及预后与先前报告相当。
