Blanchet Benoit, Charachon Antoine, Lukat Stéphanie, Huet Estelle, Hulin Anne, Astier Alain
Laboratory of Pharmacology and Toxicology, CHU Henri Mondor, Créteil, France.
Clin Toxicol (Phila). 2007 Sep;45(6):701-4. doi: 10.1080/15563650701517285.
We report a mixed intoxication with isopropyl alcohol and propanol-1 in a hospitalized patient who ingested, on two separate days, two 100 ml bottles of a topical antiseptic solution containing isopropyl alcohol and propanol-1. Eight hours after the second ingestion, plasma concentrations of isopropanol, propanol-1 and acetone were 37 mg/dL, <10 mg/dL, and 227 mg/dl, respectively. Despite a lack of severe toxicity, 4-methylpyrazole (fomepizole) was initiated. This case points out the need to limit access to alcohol-containing antiseptic solutions on wards where alcoholic and psychotic patients are hospitalized.
我们报告了一例住院患者同时摄入异丙醇和1-丙醇导致的混合性中毒病例。该患者在两天内分别摄入了两瓶100毫升含有异丙醇和1-丙醇的外用消毒溶液。第二次摄入8小时后，血浆中异丙醇、1-丙醇和丙酮的浓度分别为37毫克/分升、低于10毫克/分升和227毫克/分升。尽管没有严重毒性，但仍开始使用4-甲基吡唑（甲吡唑）进行治疗。该病例指出，在收治酗酒和精神病患者的病房，需要限制含酒精消毒溶液的获取。
