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一例因摄入外用消毒溶液后出现异丙醇和1-丙醇混合中毒的病例。

A case of mixed intoxication with isopropyl alcohol and propanol-1 after ingestion of a topical antiseptic solution.

作者信息

Blanchet Benoit, Charachon Antoine, Lukat Stéphanie, Huet Estelle, Hulin Anne, Astier Alain

机构信息

Laboratory of Pharmacology and Toxicology, CHU Henri Mondor, Créteil, France.

出版信息

Clin Toxicol (Phila). 2007 Sep;45(6):701-4. doi: 10.1080/15563650701517285.

Abstract

We report a mixed intoxication with isopropyl alcohol and propanol-1 in a hospitalized patient who ingested, on two separate days, two 100 ml bottles of a topical antiseptic solution containing isopropyl alcohol and propanol-1. Eight hours after the second ingestion, plasma concentrations of isopropanol, propanol-1 and acetone were 37 mg/dL, <10 mg/dL, and 227 mg/dl, respectively. Despite a lack of severe toxicity, 4-methylpyrazole (fomepizole) was initiated. This case points out the need to limit access to alcohol-containing antiseptic solutions on wards where alcoholic and psychotic patients are hospitalized.

摘要

我们报告了一例住院患者同时摄入异丙醇和1-丙醇导致的混合性中毒病例。该患者在两天内分别摄入了两瓶100毫升含有异丙醇和1-丙醇的外用消毒溶液。第二次摄入8小时后,血浆中异丙醇、1-丙醇和丙酮的浓度分别为37毫克/分升、低于10毫克/分升和227毫克/分升。尽管没有严重毒性,但仍开始使用4-甲基吡唑(甲吡唑)进行治疗。该病例指出,在收治酗酒和精神病患者的病房,需要限制含酒精消毒溶液的获取。

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