Calderón Rivera Jaime Salvador, Rosas Vargas Miguel Angel, Mejía Rodríguez Silvia Anett, Moncada Alcón Abel Marcelo, Río del Navarro Blanca Estela, Sienra Monge Juan José Luis
Departamento de Alergia e Inmunología Clínica, Hospital Infantil de México Federico Gómez.
Rev Alerg Mex. 2007 May-Jun;54(3):96-103.
Atopic dermatitis is an inflammatory process characterized by a series of cutaneous alterations of typical morphology and distribution, with intense pruritus of nocturnal predominance, of chronic evolution, stational appearance, and with personal and family history of atopy. On genetically predisposed skin, dry and hypersensitive, the immune factors and other types are implicated in determining the abnormal reactions to multiple endogenous and environmental factors. The diagnosis is clinical, generally obtained by a group of signs and symptoms known as the Hanifin and Rajka criteria. The patients with atopic dermatitis can present with clinical typical manifestations, or minimized and localized variations as well, considered a stigma of atopic constituent. In some patients there can be observed clinical and morphological variations with special localizations denominated atypical variations of atopic dermatitis. The identification of these atypical presentations of atopic dermatitis leads to the differential diagnosis, with an early establishment of the disease's diagnosis and the appropriate and early treatment.
特应性皮炎是一种炎症过程,其特征为一系列具有典型形态和分布的皮肤改变,伴有以夜间为主的剧烈瘙痒,呈慢性病程、有季节性发作,且患者有个人及家族特应性病史。在遗传易感性皮肤(干燥且过敏)上,免疫因素及其他类型的因素参与决定对多种内源性和环境因素的异常反应。诊断基于临床,通常依据一组被称为汉内芬(Hanifin)和拉伊卡(Rajka)标准的体征和症状得出。特应性皮炎患者可表现出临床典型表现,也可出现症状减轻和局限化的情况,后者被视为特应性体质的一种特征。在一些患者中,可观察到具有特殊部位表现的临床和形态学变化,称为特应性皮炎的非典型变化。识别这些特应性皮炎的非典型表现有助于进行鉴别诊断,从而早期确诊疾病并进行适当的早期治疗。