Alanis Fuentes José, Martínez Gutiérrez Martel, Mata Miranda Pilar
Hospital General Dr. Manuel Gea González, México.
Ginecol Obstet Mex. 2007 May;75(5):253-8.
To describe morphological and histological findings in postmenopausal patients with abnormal uterine bleeding.
An open, descriptive, observational, retrospective and cross sectional study was done at Clinica de Histeroscopia at Hospital Dr. Manuel Gea Gonzalez, in Mexico City. There were included 372 patients with postmenopausal abnormal uterine bleeding diagnosis without hormone replacement therapy. Hysteroscopy study was made with a 5 mm surgical hysteroscope using warm saline solution (280C) as a medium of distension, and a trans-hysteroscopy endometrial biopsy was taken for histopathological correlation. Statistic analysis was obtained using SPSS program version 10 for windows with a kappa test. In order to analyze more than two samples, we used the chi-square test.
Endometrial atrophy was the most frequent hysteroscopic diagnosis (202 patients, 54.3%), followed by polyps (93 patients, 25%), cancer (14 patients, 4%) and hyperplasia (11 patients, 2.95%). Correlated results between hysteroscopic findings and hystopathological biopsy diagnosis obtained were: atrophy (157 cases, 63.3%), polyps (76 cases, 77.55%), endometrial cancer (14 cases, 93.05%), endometrial hyperplasia (10 cases, 90.63%) and miomatosis (three cases, 16.20%).
It can be stated that there is a high level of concordance between findings of hysteroscopic studies and the directed endometrial biopsy. So, we recommend initially the use of hysteroscopy for diagnosis and treatment of endometrial cavity malignant and benign pathology.
描述绝经后异常子宫出血患者的形态学和组织学发现。
在墨西哥城曼努埃尔·盖亚·冈萨雷斯博士医院的宫腔镜诊所进行了一项开放性、描述性、观察性、回顾性横断面研究。纳入372例诊断为绝经后异常子宫出血且未接受激素替代治疗的患者。使用5毫米手术宫腔镜,以温生理盐水溶液(28℃)作为扩张介质进行宫腔镜检查,并进行经宫腔镜子宫内膜活检以进行组织病理学对照。使用适用于Windows的SPSS 10版程序进行统计学分析,并进行kappa检验。为了分析两个以上的样本,我们使用卡方检验。
子宫内膜萎缩是最常见的宫腔镜诊断结果(202例,54.3%),其次是息肉(93例,25%)、癌症(14例,4%)和增生(11例,2.95%)。宫腔镜检查结果与组织病理学活检诊断结果的相关性为:萎缩(157例,63.3%)、息肉(76例,77.55%)、子宫内膜癌(14例,93.05%)、子宫内膜增生(10例,90.63%)和平滑肌瘤(3例,16.20%)。
可以说,宫腔镜检查结果与定向子宫内膜活检结果之间具有高度一致性。因此,我们建议首先使用宫腔镜检查来诊断和治疗子宫内膜腔的恶性和良性病变。