Iversen P, Rasmussen F, Holm H H
Department of Urology, Herlev Hospital, University of Copenhagen, Denmark.
Scand J Urol Nephrol Suppl. 1991;138:109-15.
Transperineal 125-iodine seed implantation guided by transrectal ultrasonography and subsequent external beam irradiation was employed in the treatment of 32 patients with localized prostatic carcinoma (16 poorly differentiated). Follow-up is currently 35-98 months with a median of 65 months. Distant metastases have developed in 18 patients, of whom 11 have died from prostatic cancer. Median change in prostatic volume was a reduction of 35%. Re-biopsy or transurethral resection of the prostate was performed in 25 patients after 1-4 years, revealing still malignant histology in 10 (40%), of whom 8 have developed distant metastases or died from prostatic cancer. Fourteen patients suffered from late complications of which surgical intervention was indicated in five cases. Nine patients are presently free of progression and prostate specific antigen is less than 0.5 ng/ml in 8 of these. The future role of ultrasonically guided implantation in the management of prostatic cancer is discussed.
采用经直肠超声引导下经会阴¹²⁵碘粒子植入及随后的外照射治疗32例局限性前列腺癌患者（16例为低分化癌）。目前随访35 - 98个月，中位随访时间为65个月。18例患者发生远处转移，其中11例死于前列腺癌。前列腺体积的中位变化为缩小35%。1 - 4年后对25例患者进行了再次活检或经尿道前列腺切除术，其中10例（40%）仍显示恶性组织学，其中8例发生远处转移或死于前列腺癌。14例患者出现晚期并发症，其中5例需要手术干预。目前有14例患者病情无进展，其中8例患者的前列腺特异性抗原低于0.5 ng/ml。文中讨论了超声引导下植入在前列腺癌治疗中的未来作用。
