Iversen P, Bak M, Juul N, Laursen F, von der Maase H, Nielsen L, Rasmussen F, Torp-Pedersen S, Holm H H
Department of Urology, University of Copenhagen, Denmark.
Urology. 1989 Oct;34(4):181-6. doi: 10.1016/0090-4295(89)90368-3.
Thirty-three patients with localized prostatic carcinoma (16 poorly differentiated) were treated with transperineal 125Iodine seed implantation (160 Gy) guided by transrectal ultrasonography and subsequent external beam irradiation (47.4 Gy). The observation time was six to sixty-eight months with a median follow-up of thirty-five months. Median change in prostatic volume was a reduction of 35 percent. Re-biopsy or transurethral resection of the prostate was performed in 25 patients after one to two years, revealing still malignant histology in 12 (48%). Development of distant metastases occurred in 14 patients (44%), and 8 have died of prostatic cancer. Fourteen patients suffered from late complications of which surgical intervention was indicated in 3 cases.
33例局限性前列腺癌患者（16例为低分化癌）接受了经直肠超声引导下的经会阴¹²⁵碘粒子植入（160Gy）及随后的外照射（47.4Gy）治疗。观察时间为6至68个月，中位随访时间为35个月。前列腺体积的中位变化为缩小35%。1至2年后，25例患者接受了再次活检或经尿道前列腺切除术，其中12例（48%）组织学检查仍显示为恶性。14例患者（44%）发生远处转移，8例死于前列腺癌。14例患者出现晚期并发症，其中3例需要手术干预。
