Hammer J
Abteilung für Strahlentherapie des Krankenhauses der Barmherzigen Schwestern, Linz, Osterreich.
Strahlenther Onkol. 1991 Feb;167(2):63-81.
From February 1981 until August 1984 20 patients (group A) with localized prostate cancer were treated by radical pelvic lymphadenectomy and direct 125-Iodine seed implantation. From September 1984 until January 1988 51 patients (group B) underwent a modified diagnostic pelvic lymphadenectomy: four weeks later the transperineal seed implantation, guided by rectal ultrasound, followed. The follow-up period in group A is 90 months (range 72 to 114), in group B 48 months (range 30 to 70). Nine patients of group A presented with a progression of disease, four died with/of disease. Ten patients of group B developed distant metastases, three of them presented with both, distant disease and local recurrence: one patient died of disease. The Kaplan-Meier five-year survival probability is 82.3% in group A, and 96.5% in group B: the disease-free survival 62.3% and 75.2% respectively. The probability of local control is 78% in group A and 93.5% in group B. In group A there is a higher incidence of complications compared to group B, in particular concerning edemas of the legs and the genital region. The rate of impotence after seed implantation is very low (2/57 = 3.5%).
1981年2月至1984年8月，20例局限性前列腺癌患者（A组）接受了根治性盆腔淋巴结清扫术及直接碘-125粒子植入术。1984年9月至1988年1月，51例患者（B组）接受了改良诊断性盆腔淋巴结清扫术：四周后在直肠超声引导下经会阴进行粒子植入。A组随访期为90个月（范围72至114个月），B组为48个月（范围30至70个月）。A组9例患者出现疾病进展，4例死于疾病。B组10例患者发生远处转移，其中3例同时出现远处疾病和局部复发：1例患者死于疾病。A组的Kaplan-Meier五年生存率为82.3%，B组为96.5%；无病生存率分别为62.3%和75.2%。A组局部控制率为78%，B组为93.5%。与B组相比，A组并发症发生率更高，尤其是腿部和生殖器区域的水肿。粒子植入术后阳痿发生率很低（2/57 = 3.5%）。
