Ryabukhin Sergey V, Plaskon Andrey S, Ostapchuk Eugeniy N, Volochnyuk Dmitriy M, Shishkin Oleg V, Shivanyuk Alexander N, Tolmachev Andrey A
Enamine Ltd., 23 A. Matrosova st., 01103 Kyiv, Ukraine.
Org Lett. 2007 Oct 11;9(21):4215-8. doi: 10.1021/ol701782v. Epub 2007 Sep 12.
The chlorotrimethylsilane-promoted Biginelli type reactions of aldehydes, thiourea, and cyanoketones led to a diverse set of tetrahydropyrimidine-2(1H)-thiones. Under similar conditions, thioureas, benzaldehyde, and cyanoacetamide reacted to give first representatives of hexahydro-5H-pyrimido[5,4-e][1,3]thiazin-5-ones in high preparative yield.
