Enamine Ltd, 23 A. Matrosova St., Kyiv, 01103, Ukraine.
Mol Divers. 2011 Feb;15(1):189-95. doi: 10.1007/s11030-010-9253-6. Epub 2010 May 7.
Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the synthesis of diverse dihydropyrimidines via Biginelli type MCR-heterocyclization using aminoheterocycles. High yields and a simple workup of target compounds enable the facile generation of combinatorial libraries comprising more than 2,000 compounds of high structural and functional diversity. A representative set of 89 compounds is described.
三甲基氯硅烷 (TMSCl) 已被用作一种高效的促进剂和除水剂，用于通过使用氨基杂环的 Biginelli 型 MCR-杂环化反应合成各种二氢嘧啶。高产率和目标化合物的简单后处理使得可以轻松生成包含 2000 多种具有高结构和功能多样性的组合文库。描述了一组 89 种代表性化合物。
