拓展普默勒尔反应化学。海鞘素生物碱领域的合成研究。
Extending Pummerer reaction chemistry. Synthesis studies in the phakellin alkaloid area.
作者信息
Feldman Ken S, Skoumbourdis Amanda P, Fodor Matthew D
机构信息
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
出版信息
J Org Chem. 2007 Oct 12;72(21):8076-86. doi: 10.1021/jo701487j. Epub 2007 Sep 13.
PMID:17850163
Abstract
The syntheses of (+/-)-dibromophakellstatin and, from this species, (+/-)-dibromophakellin are described. Oxidative cyclization of a phenylthiolated dihydrooroidin derivative triggered by a Pummerer reaction constitutes the key step in this biomimetic approach to this family of marine alkaloids.
摘要
描述了（±）-二溴法卡他汀以及从该物种中得到的（±）-二溴法卡林的合成。由普默勒尔反应引发的苯硫基化二氢奥瑞定衍生物的氧化环化是这种仿生合成该类海洋生物碱方法的关键步骤。
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