Hattrup Christine L, Gendler Sandra J
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AR 85259, USA.
Annu Rev Physiol. 2008;70:431-57. doi: 10.1146/annurev.physiol.70.113006.100659.
Cell surface mucins are large transmembrane glycoproteins involved in diverse functions ranging from shielding the airway epithelium against pathogenic infection to regulating cellular signaling and transcription. Although hampered by the relatively recent characterization of cell surface mucins and the difficulties inherent in working with molecules of their size, numerous studies have placed the tethered mucins in the thick of normal and diseased lung physiology. This review focuses on the three best-characterized cell surface mucins expressed in the respiratory tract: MUC1, MUC4, and MUC16.
细胞表面黏蛋白是大型跨膜糖蛋白，参与多种功能，从保护气道上皮免受病原体感染到调节细胞信号传导和转录。尽管细胞表面黏蛋白相对较新的特征描述以及处理其大小的分子所固有的困难阻碍了研究，但众多研究已将拴系黏蛋白置于正常和患病肺生理学的核心位置。本综述重点关注呼吸道中表达的三种特征最为明确的细胞表面黏蛋白：MUC1、MUC4和MUC16。
