Dillon Daniel G, Holmes Avram J, Jahn Allison L, Bogdan Ryan, Wald Lawrence L, Pizzagalli Diego A
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA.
Psychophysiology. 2008 Jan;45(1):36-49. doi: 10.1111/j.1469-8986.2007.00594.x. Epub 2007 Sep 10.
Incentive delay tasks implicate the striatum and medial frontal cortex in reward processing. However, prior studies delivered more rewards than penalties, possibly leading to unwanted differences in signal-to-noise ratio. Also, whether particular brain regions are specifically involved in anticipation or consumption is unclear. We used a task featuring balanced incentive delivery and an analytic strategy designed to identify activity specific to anticipation or consumption. Reaction time data in two independent samples (n=13 and n=8) confirmed motivated responding. Functional magnetic resonance imaging revealed regions activated by anticipation (anterior cingulate) versus consumption (orbital and medial frontal cortex). Ventral striatum was active during reward anticipation but not significantly more so than during consumption. Although the study features several methodological improvements and helps clarify the neural basis of incentive processing, replications in larger samples are needed.
奖励延迟任务表明纹状体和内侧前额叶皮质参与奖励处理。然而，先前的研究给予的奖励多于惩罚，这可能导致信噪比出现不必要的差异。此外，特定脑区是否专门参与预期或消费尚不清楚。我们使用了一个具有平衡奖励发放的任务和一种旨在识别预期或消费特定活动的分析策略。两个独立样本（n = 13和n = 8）中的反应时间数据证实了有动机的反应。功能磁共振成像显示了预期激活的区域（前扣带回）与消费激活的区域（眶额和内侧前额叶皮质）。腹侧纹状体在奖励预期期间活跃，但并不比消费期间显著更活跃。尽管该研究有几个方法上的改进，并有助于阐明奖励处理的神经基础，但仍需要在更大样本中进行重复研究。
