Lin C-T, Petersen-Jones S M
Department of Veterinary Medicine, National Taiwan University Veterinary Hospital, College of Bio-Resources and Agriculture, National Taiwan University, Taipei 106, Taiwan.
J Small Anim Pract. 2008 Feb;49(2):80-3. doi: 10.1111/j.1748-5827.2007.00437.x. Epub 2007 Sep 7.
To assess the antibiotic susceptibility of bacteria isolated from corneal ulcers in cats.
A total of 92 cats with infected corneal ulcers were swabbed for bacterial culture and the antibiotic sensitivity of the isolates analysed.
Bacteria were isolated from 54 of 92 infected eyes with corneal ulcers and purulent discharge. A total of 59 bacterial isolates were obtained from the 54 ulcers. The ratio of Gram-positive to Gram-negative isolates was approximately 3:1. The most commonly isolated Gram-positive bacteria were Staphylococcus species (51 per cent of all isolates), while Pseudomonas aeruginosa (13.5 per cent of all isolates) was the most common Gram-negative bacteria isolated. The Gram-negative isolates demonstrated a greater incidence of antibiotic resistance than the Gram-positive ones. The most effective antibiotics against the isolates were ciprofloxacin, tobramycin and gentamicin, with erythromycin and lincomycin showing the greatest number of resistant isolates.
Staphylococcus and Pseudomonas species were the most common Gram-positive and Gram-negative bacteria, respectively, isolated from feline eyes with ulcerative keratitis. The second-generation fluoroquinolone, ciprofloxacin and the aminoglycoside gentamicin were found to be highly effective against the majority of isolates.
评估从猫角膜溃疡分离出的细菌的抗生素敏感性。
对92只患有感染性角膜溃疡的猫进行拭子采样以进行细菌培养，并分析分离株的抗生素敏感性。
在92只患有角膜溃疡并伴有脓性分泌物的感染眼中，有54只分离出细菌。从这54处溃疡中共获得59株细菌分离株。革兰氏阳性菌与革兰氏阴性菌分离株的比例约为3:1。最常分离出的革兰氏阳性菌是葡萄球菌属（占所有分离株的51%），而铜绿假单胞菌（占所有分离株的13.5%）是最常分离出的革兰氏阴性菌。革兰氏阴性菌分离株的抗生素耐药发生率高于革兰氏阳性菌。对分离株最有效的抗生素是环丙沙星、妥布霉素和庆大霉素，而红霉素和林可霉素的耐药分离株数量最多。
葡萄球菌属和假单胞菌属分别是从患有溃疡性角膜炎的猫眼中最常分离出的革兰氏阳性菌和革兰氏阴性菌。发现第二代氟喹诺酮类药物环丙沙星和氨基糖苷类药物庆大霉素对大多数分离株高度有效。
