Simmons E H, Graziano G P, Heffner R
University Orthopaedic Spine Service, State University of New York, Buffalo.
Spine (Phila Pa 1976). 1991 Aug;16(8 Suppl):S351-60.
The effects of ankylosing spondylitis on skeletal muscle were investigated in nine consecutive patients referred for correction of severe spinal deformity. Enzymatic studies (creatinine phosphokinase, aldolose), electromyography, and paraspinal muscle biopsy were performed. The enzyme studies and electromyography yielded only variable results, but muscle biopsy uniformly demonstrated evidence of severe skeletal muscle disease. Small, scattered, sharp angular fibers were present in all specimens along with atrophy of Type I and Type II muscle fibers. Core or targetoid fibers were present in all but one patient. These findings suggest that muscle disease may be present in all ankylosing spondylitis patients with spinal flexion deformity.
对9例因严重脊柱畸形前来矫正的连续患者，研究了强直性脊柱炎对骨骼肌的影响。进行了酶学研究（肌酸磷酸激酶、醛缩酶）、肌电图检查和椎旁肌活检。酶学研究和肌电图检查结果不一，但肌肉活检均显示出严重骨骼肌疾病的证据。所有标本中均存在小的、散在的、尖锐角状纤维，同时伴有I型和II型肌纤维萎缩。除1例患者外，其他患者均存在核心或靶样纤维。这些发现提示，所有有脊柱屈曲畸形的强直性脊柱炎患者可能都存在肌肉疾病。
