Cooper R G, Freemont A J, Fitzmaurice R, Alani S M, Jayson M I
Rheumatic Diseases Centre, University of Manchester, Hope Hospital, Salford, United Kingdom.
Ann Rheum Dis. 1991 Nov;50(11):755-9. doi: 10.1136/ard.50.11.755.
The histological appearance of percutaneous superficial paraspinal muscle biopsy specimens from eight patients with ankylosing spondylitis was compared with that of biopsy specimens from 13 control patients with similar degrees of disability and spinal immobility due to severe, chronic mechanical back pain. In both groups marked type II muscle fibre atrophy was shown. Additionally, in patients with ankylosing spondylitis there were obvious increases in perifibre connective tissue in association with central migration of cell nuclei but without evidence of inflammation. Qualitative electromyography failed to show denervation changes in either group. Paraspinal muscle fibrosis, occurring over and above atrophic changes due to disuse, seems to be a specific pathological component of ankylosing spondylitis which may be of particular importance in early disease as it may contribute towards back stiffness and weakness.
将8例强直性脊柱炎患者的经皮椎旁浅层肌肉活检标本的组织学表现，与13例因严重慢性机械性背痛导致类似残疾程度和脊柱活动受限的对照患者的活检标本进行比较。两组均显示出明显的II型肌纤维萎缩。此外，强直性脊柱炎患者的纤维周围结缔组织明显增加，伴有细胞核向中央迁移，但无炎症迹象。定性肌电图未显示两组有失神经改变。椎旁肌纤维化，除了因废用引起的萎缩性改变外，似乎是强直性脊柱炎的一种特定病理成分，在疾病早期可能特别重要，因为它可能导致背部僵硬和无力。
